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How Monoclonal Antibodies Prevent Migraine

While all of the drugs work on CGRP, they don’t all work the same way. Three of them target the CGRP molecule itself. Aimovig goes after CGRP's receptor in the brain.

"You can think of the CGRP molecule as a key that unlocks a door to activate a particular brain mechanism, and you can think of the receptor as the lock the key fits into," says Lipton, who's also the Edwin S. Lowe professor and vice chairman of neurology at Albert Einstein College of Medicine. It's possible that if a CGRP-targeting drug doesn't work for someone, a drug that targets the receptor might, he says.

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